|
 |
 |
Massimo Sisto
MSc Student |
I recently completed my Bachelor's
degree in Pharmacology at McGill, with a focus on
chemistry and psychology, and have since joined the
Hébert Lab as a Master's student. I am fascinated by
psychoactive substances and applying molecular
structures to design therapeutics that are highly
specific to a given receptor. I was very excited to work
on an undergraduate project in the Hébert lab where I
helped to characterize signaling pathways activated by
psychedelic analogues targeting the 5HT2A receptor. I am
now studying urotensin and angiotensin receptor
heterodimers (both implicated in cardiac pathology)
using BRET-based biosensors to determine how signaling
is affected by dimerization and if interfering with
these dimers can lead to a clinical benefit in the
treatment of cardiac fibrosis. To this end, I will be
collaborating with the Chatenet lab to design peptides
to disrupt the dimer interface based on computational
models. In my free time, I enjoy playing outdoor hockey,
listening to music, watching action movies and playing
video games.
